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It typically presents as macrocytic megaloblastic anemia and neurological impairments, including sensory and motor disfunctions, predominantly in the lower extremities, ataxia, and in more advanced stages cognitive decline progressing to dementia, as well as psychiatric disturbances (Sanjay et al., 2022

Homeostatic control of zinc metabolism in men: Zinc excretion and balance in men fed diets low in zinc

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Required Medical Stability: Patients must not have decompensated neurological conditions (e.g., advanced multiple sclerosis or Parkinsons disease), as these may affect the therapys ability to restore normal sleep patterns

In conclusion, further investigation is warranted to elucidate the underlying pathways and regulatory mechanisms associated with ferroptosis in PF

Another example of polyphenols is resveratrol, which has been reported to have various biological properties such as immunomodulation, antioxidation, hepatoprotection, anti-inflammation, regulation of lipid metabolism, and others (158160)