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Although habitual napping has been correlated with negative cognitive and physical health outcomes, especially in older individuals, occasional short naps in the early afternoon may improve mental and emotional function without disrupting the sleep-wake cycle

This neurovascular coupling could be elucidated by monitoring the dynamic changes of the regional cerebral arterial blood flow

(C) Acquired resistance mechanisms: Acquired resistance is mediated by secondary mutations in the target protein, activation of alternative pathways through other receptors or downstream proteins, or phenotypic transformation