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Additionally, the applicant stated that VANFLYTA, if approved, would be the only AML drug indicated for continuation monotherapy following consolidation chemotherapy (for up to 3 years), based on showing activity as a single agent for that use, and that therefore, the technology meets the newness criterion

(2016, November)

Burns JM, et al

Additionally, conditions such as laryngopharyngeal reflux (LPR), throat infections , or even tumours in the throat or oesophagus can cause persistent burning sensations

This is consistent with the different types of damage caused by IR versus UV radiation and the different DNA repair pathways that are used (eg, DNA DSBs and single-strand breaks, repaired by HR and NHEJ versus cyclobutane pyrimidine dimers (CPDs) and 6-4PPs repaired by NER, respectively (see Chap