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For instance, exposure to tobacco smokes polycyclic aromatic hydrocarbons can stimulate the activity of CYP1A1 and CYP1A2, possibly changing the biotransformation of antidepressants and antipsychotics ( This link between environmental factors and CYP450 activity has direct clinical relevance

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Additionally, VIP has immunomodulatory properties, influencing immune cell functions and inflammatory responses (Delgado et al., 2004)

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