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Calcium (Ca) and Glutathione (GSH) are signaling molecules to scavenge free radicals in HM-stressed plants

References Jelovac, N., Sikiri, P., Rucman, R., Petek, M., Perovi, D., Konjevoda, P., Marovi, A., Seiwerth, S., Grabarevi, Z., Sumajstorci, J., Dodig, G., & Peri, J

Libby RT, Howell GR, Pang IH, Savinova OV, Mehalow AK, et al

Collaboration between academic institutions, pharmaceutical companies and regulatory authorities is essential to establish standardized protocols for biomarker validation and expand pharmacogenomic databases

Modified from Palaiologos et al

However, unlike necrosis, pyroptosis was initially described as a type of programmed cell death that, rather than being quiet, like apoptosis, triggers a robust inflammatory response, including the recruitment of immune cells to the site of death (Boise and Collins, 2001