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Recently, it has been reported that combination of statins (atorvastatin, fluvastatin and simvastatin) and conventional chemotherapy (topotecan, paclitaxel and doxorubicin) acted synergistically to inhibit cell proliferation and to induce cytotoxicity in an aggressive natural killer cell leukemia (221)

J Midwifery Womens Health 2002 Nov-Dec

However, the efficacy of this strategy in the context of vascular aging remains to be elucidated, prompting our further investigation in this area

Sustained inflammatory activation can, in turn, promote hepatic stellate cell (HSC) activation and extracellular matrix deposition, thereby contributing to fibrogenesis