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Nguyen et al., 2018

According to the results of a meta-analysis based on fifteen studies enrolling a total of 1633 tumor patients, positive expression of CD44v9 was associated with poor overall survival and relapse-free survival, compared with cancer patients with negative expression of CD44v9 [127]

Other natural interventions that may benefit patients with IBD include L-carnitine , glutamine , melatonin , vitamin K , and others

Acetate, propionate, and butyrate are essential microbial metabolites that in addition to host-centric functions in energy metabolism and immunological control, affect bacterial communities by modifying luminal pH, suppressing pathogenic overgrowth, and regulating quorum-sensing pathways 43

Coenzyme Q10 (ubiquinone) has been used in oral forms to treat various cardiovascular disorders including angina pectoris, hypertension, and CHF (Greenberg ER, et al ., 1996)

The metabolite analysis demonstrated that Nrf2 strongly promotes purine nucleotide synthesis, resulting in the increased production of purine nucleotides