In low pH (below c
Disclosures: Wen Zhang: Nothing to Disclose, Wenyue Wu: Nothing to Disclose, Ning Zhang: Nothing to Disclose, Hong Li: Nothing to Disclose, Yameng Sun: Nothing to Disclose, Xiaodong Ge: Nothing to Disclose, Hui Han: Nothing to Disclose, Shuyan Chen: Nothing to Disclose, Anjian Xu: Nothing to Disclose, Sai Santosh Babu Komakula: Nothing to Disclose, Chao Wang: Nothing to Disclose, Nithyananthan Subramaniyam: Nothing to Disclose, Qi Han: Nothing to Disclose, Xuzhen Yan: Nothing to Disclose, Aiting Yang: Nothing to Disclose, Natalia Nieto: Nothing to Disclose, Hong You: Nothing to Disclose, Wei Chen: Nothing to Disclose 2043 NOVEL BLOOD-BASED BIOMARKER MODEL FOR DIAGNOSIS OF HEPATIC FIBROSIS IN MASLD Eveline Gart Lars Verschuren 1 Anne Mak 2 Andre Boonstra 3 Joanne Verheij 4 Lise Lotte Gluud 5 Adriaan Holleboom 2 Maarten Tushuizen 6 , 1 TNO, 2 Amsterdam UMC, 3 Erasmus University Medical Center, 4 Academic Medical Center, 5 Copenhagen University - Hvidovre Hospital, 6 LUMC Background: Considering the escalating prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and related fibrosis, accurate non-invasive biomarkers for diagnosis and staging of fibrosis are urgently needed
Indole-3-acetic acid (IAA), produced by gut microbiota, alleviates fibrosis by suppressing PI3K/AKT/mTOR signaling, enhancing autophagy, and reducing fibroblast activation and epithelial senescence [114]
Meanwhile, an in vitro study also showed that combination of LPS and (1 3)--D-glucan increased expression of IL-6 and TNF- in supernatant of HK-2 cells and upregulation expression of genes including Dectin-1 and Toll-like receptor 4, which promote inflammatory and fibrotic processes [121]
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