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The pathogenesis of myelodysplastic syndrome (MDS) and erythropoiesis involve PLC-1/protein kinase C (PKC) signal transduction, especially nuclear PLC-1 gene (94).PLC-1a is a negative regulator of erythroid differentiation, and which is reduced in erythropoietin-responder MDS patients and in normal hematopoietic stem cell progenitors induced to erythroid differentiation (95)

Conclusion and perspectives Lactylation has emerged as a multifaceted regulatory mechanism that not only modulates gene transcription and signal transduction but also profoundly influences protein characteristics and functions

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1 2 For those who cannot speak: a history of the Canadian Society for the Prevention of Cruelty to Animals, 18691969

(2016) The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells, Free Radic