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Stimulation with 6-hydroxydopamine (6-OHDA) markedly downregulates nuclear factor erythroid 2related factor 2 (NRF2) expression in PC-12 cells, elevates Fe 2+ and reactive oxygen species (ROS) levels, suppresses glutathione peroxidase 4 (GPX4), promotes both ferroptosis and apoptosis, inhibits cell proliferation, and causes neuronal damage

Melanocytes are free of fibrillar material such as tonofibrils, desmosomes, and tonofilaments, typical for the keratinocyte

It then combines with oxygen and becomes sulfur dioxide

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Genus-level networks (Figure S6B) identified high-centrality nodes such as Paludicola and Staphylococcus, suggesting their roles as keystone taxa

However, neurologists have an essential role in managing the movement disorders manifestations that characterize TD