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When tumor cells are detached from the ECM, glucose metabolism and mitochondrial respiration are inhibited, leading to reduced cellular energy synthesis and increased intracellular ROS levels, indicating the important role of ECM adhesion in cellular metabolism (125)

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

The simulations suggested that quinone metabolism yielded an increase in ROS (O 2 . and H 2 O 2 ), producing a maximum of 0.42 M and 1 10 3 M respectively

[DOI] [PubMed] [Google Scholar] 36.Lezhava T., Jokhadze T., Monaselidze J., Buadze T., Gaiozishvili M., Sigua T

In previous studies that compared the differentiation capacity of chondrocytes from different passages, the results indicated that cells at early passages usually generated more cartilage matrix than those at late passages upon chondroinduction ( There are several limitations in the current study