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doi: 10.1016/j.jbspin.2025.105892 Summary Keywords NLRP3 inflammasome, oxidative stress, programmed cell death, sodium urate crystal, soluble uric acid Citation Yang Q, Xu Y, Zhang J, Xiao N, Lu H, Chen B, Yang B, Xie Z and Li Z (2026) From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy

The observed diabetogenic activity of OTA is attributed to its impact on degeneration of pancreatic Langerhans islets (227)

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42,43 However, these studies were criticized for small sample size, the short-term duration of the studies, the fact the studies showed correlation not causation, and the studies used higher dosages that are not typical of everyday use

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