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Warburg effect fuels growth in tumors and can weaken the EPR effect in advanced cancers, ultimately hindering effective drug delivery and challenging the clinical translation of nanomedicines 22,136

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Noyce said that there isn't an agreed definition of "heavy use," but a ballpark figure is using more than 10 to 15 canisters more than once a week, citing his own research, while the Dutch Poison Centre classes puts it at inhaling 50 or more balloons in a single session