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As previously shown, MPTP reduced tyrosine hydroxylase immunoreactivity and DA levels, and increased several markers of neuroinflammation such as microglial activation, and the expression of the inducible nitric oxide synthase, metallothionein-III, heme oxygenase 1

Table 3 Incidence and aHR of Developing CD According to Smoking Status and Onset Age of Smoking Subgroup analyses Subgroup analyses evaluated whether the relationship between the onset age of smoking and the risk of UC was influenced by sex, BMI, metabolic syndrome, alcohol consumption, or regular exercise after adjusting for age, sex, income, alcohol consumption, regular exercise, BMI, metabolic syndrome, and peak year of smoking