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Before the elucidation on KA topical cream, only BAK topical analgesic gel (0.76% baclofen, 3% amitriptyline hydrochloride, and 1.5% ketamine) exhibited slight benefit, but not enough to conclude ( Based on the evidence to date, duloxetine is still effective and well-tolerated in the treatment of CIPN

Serious adverse events were rare, and when occurred, they were not attributed to ALC

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Russo, S., Scotto Di Carlo, F

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These symptoms have often been linked to connective tissue laxity and autonomic dysfunction, which affect the structural and functional integrity of the gastrointestinal tract and the autonomic nervous systems rest and digest activity (6,14)