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469,470 A recent study demonstrated that subcutaneous injection of a CPP-DG9 and PMO conjugate improved muscle strength and innervation in mice with severe SMA, significantly extending their median survival with no apparent side effects

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In contrast, Cluster 2 (vitrified oocytes) was enriched in genes related to actin nucleation regulation, proteasome-mediated ubiquitin-dependent protein catabolism, proteasomal protein degradation, and positive regulation of autophagy

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Following a 48 hr treatment period, cells were harvested, and the genomic DNA was isolated from each sample (Fig