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AuNPs have also been employed in PD models

4.4 Epigenetic modifications and gene expression regulation Maternal gut microbiota-derived metabolites have been demonstrated to possess the potential to modulate the activity of key host epigenetic enzymes

METHODS: Animals were randomly allocated to sequentially receive atropine (0.12 mg/kg by rapid injection), pralidoxime (25 mg/kg by injection during 2 minutes), and hydroxocobalamin (75 mg/kg during 10 minutes) by the intravenous or intraosseous route, or atropine and pralidoxime by the intramuscular route

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This has a practical consequence

Cardiac-specific down-regulation of carnitine palmitoyltransferase-1b (CPT-1b) prevents cardiac remodeling in obese mice