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Sequence alignment shows that Cys180 of GSDME is conserved in human, mouse, and zebrafish (highlighted in red) (Fig

In those who completed treatment, 86% treated with triple therapy alone achieved eradication while 100% treated with triple therapy plus zinc-carnosine (150 mg twice daily) were H

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A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization